Subsequently, a growing system of proof supported the thought that CD74 might have added functions being a receptor. area expression of CD74 occurred independently of concomitant MHCII expression.
These perturbations are partly resulting from dependency on p53 [13]. This review reveals that MIF serves a job in nervous procedure development, Even though the actual mother nature of the position continues to be undefined.
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Together with MIFs immunogenic part, it's also been claimed to Perform a very important job for the duration of neural embryonic advancement. Shen et al. (2013) demonstrated that the MIF pathway is needed for that survival of statoacoustic ganglia and sensory hair cells within a zebrafish design. applying knockdown with antisense oligonucleotide morpholinos (MOs) and/or using a biochemical MIF inhibitor, four-IPP, there was a significant reduction in the scale of your SAG, the quantity of sensory HC, and the size of your Mind in zebrafish.
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